Drs A.M. Burgoyne, T.G. Kutateladze, D.L. Durden and colleagues have described now a new synthetic small molecule inhibitor with triple action against the targets CDK4/6, PI3K and… Read more “A new triple action CDK4/6-PI3K-BET inhibitor with potential for cancer treatment”
Category: Interesting research articles
Rho-family GTPases network analysis
The Rho family of GTPases are implicated in a multitude of biological processes, both in physiology and during disease. To understand their complex regulation, it is key… Read more “Rho-family GTPases network analysis”
Call for papers on Neuroblastoma Molecular Biology and Therapeutics
I am acting as Guest Editor for a special issue on Neuroblastoma Molecular Biology and Therapeutics for the International Journal of Molecular Sciences. The Journal is indexed… Read more “Call for papers on Neuroblastoma Molecular Biology and Therapeutics”
Labelling actin, at a cost
A recent paper by Flores L.R. et al. draws the attention to the possible artefacts in actin dynamics and architecture when using Lifeact to label cells in… Read more “Labelling actin, at a cost”
Genome and transcriptome analysis from childhood cancer available
Results from two collaborative efforts performing pan-cancer genomic analysis on different cohorts of tumors from children have been published and made available. These data provide a genomic… Read more “Genome and transcriptome analysis from childhood cancer available”
New evidence for microenvironment influence in neuroblastoma metastasis
A recent paper by C. Delloye-Bourgeois and collegues, from the University of Lyon, elegantly demonstrate the influence of microenvironment and cell-cell adhesion in neuroblastoma metastasis. The authors… Read more “New evidence for microenvironment influence in neuroblastoma metastasis”
The Rho effector ROCK as target for neuroblastoma tumours
In a recent paper on PNAS, C. Dyberg and collaborators describe for the first time a potential use of ROCK inhibition for neuroblastoma treatment. They show a… Read more “The Rho effector ROCK as target for neuroblastoma tumours”
New ex-vivo model for the study of endothelial progenitor cells mobilization
Dr Duran-Ruiz and colleagues have now published a new work evaluating the initial response of early Endothelial Progenitor Cells (EPC) from healthy individuals to factors released by… Read more “New ex-vivo model for the study of endothelial progenitor cells mobilization”
High αvβ3 integrin and low PTEN expression neuroblastomas as target for dual PI3K/BRD4 inhibitor
Drs A. Erdreich-Epstein, D.L. Durden and colleagues have described how high αvβ3 integrin in microvessels and low PTEN in tumor cells, detected by IHC in neuroblastoma stage… Read more “High αvβ3 integrin and low PTEN expression neuroblastomas as target for dual PI3K/BRD4 inhibitor”
New review work on RhoB
We have just published a review article with the latest research on the Rho GTPase RhoB. RhoB has similarities with their more studied sisters RhoA and RhoC,… Read more “New review work on RhoB”
Cancer Cell Biology Laboratory 