Research Publications

  • Vega, F.M., Gautier, V., Fernandez-Ponce, C.M., Maarten, A.F., Tellez, J.T., Hernandez-Campos, J.A., Millan, J., Pardal, R., Garcia-Cózar, F.J., Aguado, E., Heck, A.J.R. and Duran-Ruiz, M.C. “The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo” (2017) J Mol Cell Cardiology. Feb18. [Epub ahead of print]
  • Vega, F.M.* and Ridley, A.J. “The RhoGTPase RhoB in physiology and disease” (2016) Small GTPases Nov. 22:1-10 (*Corresponding author)
  • Erdreich-Epstein, A., Singh, A.R., Joshi, S., Vega, F.M., Guo, P., Xu, J., Groshen, S., Millard, M., Campan, M., Morales, G., Garlich, J.R., Laird, P.W., Seeger, R.C., Shimada, H. and Durden, D.L. “ Association of high microvessel αvβ3 and low PTEN with poor outcome in Stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126” (2016) Oncotarget Nov 16.
  • Moura, D.S., Fernández, I.F., Marín-Royo, G., López-Sánchez, I., Martín-Doncel, E., Vega, F.M. and Lazo, P.A. “Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation” (2016) Sci. Rep. 6:28532.
  • Vega, F.M.*, Reymond, N., Thomas, M. and Ridley, A.J.*RhoB controls epithelial cell-cell adhesions by regulating E-Cadherin dynamics” (2015) Cell Commun Signal. Jan29;13:6 (*Corresponding authors)
  • Martínez-Criado Y., Cabello R., Fernández-Pineda I., Márquez C., Ramírez G., Rivas E., Robles M.J., Pardal R., Vega F.M.Study of the expression of neural stem cell markers in neuroblastoma tumor samples and correlation with prognostic factors”(2013) Cir Pediatr. Jul;26(3):112-8.[Spanish]
  • Reymond, N., Im, J.H., Gag, Ritu, Vega, F.M., Borda d’Agua, B., Riou, P., Cox, S., Valderrama, F., Muschel, R. J. & Ridley, A. J. “Cdc42 promotes transendothelial migration of cancer cells through BETA1 integrin” (2012) J. Cell Biol. 199(4): 653 – 68.
  • Reymond, N., Vega, F.M. & Ridley, A.J. “RhoC (RHOC)” (2012) Encyclopedia of Signaling Molecules. Choi, S. (ed.) Springer-Verlag. ISBN: 978-1-4419-0460-7. pp : 1664-1668.
  • Valbuena, A., Sanz-García, M., López-Sánchez, I., Vega, F. M., Sevilla, A. & Lazo, P.A. “VRK1: vaccinia-related kinase 1” (2012) Encyclopedia of Signaling Molecules. Choi, S. (ed.) Springer-Verlag. ISBN: 978-1-4419-0460-7. pp : 1992-1996.
  • Vega, F.M., Colomba, A., Reymond, N., Thomas, M. and Ridley, A.J. “RhoB regulates cell migration through altered focal adhesion dynamics” (2012) Open Biology. May;2(5):120076.
  • Vega F.M., Fruhwirth G., Ng T., Ridley A.J. “RhoA and RhoC have distinct roles in migration and invasion by acting through different targets” (2011) J Cell Biol. 193(4): 655-65.
  • Valbuena A., Sanz-García M., López-Sánchez I., Vega F.M., Lazo P.A. “Roles of VRK1 as a new player in the control of biological processes required for cell division” (2011) Cell Signal. 23(8), 1267-72.
  • Duran, M.C., Vega, F.M., Moreno-Bueno, G., Artiga, M.J., Sanchez, L., Palacios, J., Ridley, J. and Timms, J.F. “Characterisation of tumoral markers correlated with ErbB2 (HER2/Neu) overexpression and metastasis in breast cancer” (2008) Proteomics Clin Appl., 2, 1313-1326.
  • Vega, F.M. and Ridley, A.J. “Rho GTPases in Cancer Cell Biology” (2008) FEBS Lett. Jun 18;582(14):2093-101.
  • Valbuena A., Blanco S., Vega F.M. and Lazo P.A. “The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53” (2008) PLoS One. Jul 9;3(7):e2649.
  • Lazo P.A., Vega F.M., Sevilla A., Valbuena A., Sanz-García M., López-Sanchez I., Blanco S. “VRK1 (Vaccinia-related kinase 1)” (2007) Atlas Genet Cytogenet Oncol Haematol.;11(4):285-288.
  • Valbuena, A., Lopez-Sanchez, I., Vega, F.M., Sevilla, A., Sanz-Garcia M., Blanco, S., and Lazo, P.A. “Identification of a human epitope in human vaccinia-related Kinase 1 (VRK1) and detection of different intracellular subpopulations” (2007) Arch Biochem Biophys. Sep 1;465(1):219-26. Epub 2007 Jun 14.
  • Vega, F.M. and Ridley, A.J. “SnapShot: Rho Family GTPases” (2007) Cell. Jun 29;129(7): 1430.
  • *Valbuena, A., *Vega, F.M. and Lazo, P.A. “p53 downregulates its activating Vaccinia-related kinase 1 (VRK1) forming a new autoregulatory loop” (2006) Mol Cell Biol. Jul;26(13): 4782-93. [*both authors contributed equally to the work]
  • Wheeler, A.P., Wells, C., Smith, S.D., Vega, F.M., Henderson, R.B., Tybulewicz, V.L. and Ridley, A.J. “Rac1 and Rac2 regulate macrophage morphology but are not essential for migration” (2006) J Cell Sci. Jul 1;119(Pt 13): 2749-57.
  • Blanco, S., Klimcakova, L., Vega, F.M. and Lazo, P. A. “Subcellular localization of vaccinia-related kinase 2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines” (2006) FEBS J. Jun;273(11):2487-504.
  • Santos, C.R., Rodriguez-Pinilla, M., Vega, F.M., Rodriguez-Peralto, J.L., Blanco, S., Sevilla, A., Valbuena, A., Hernandez, T., van Wijnen, A.J., Li, F., de Alava, E., Sanchez-Cespedes, M., Lazo, P.A. “VRK1 Signaling Pathway in the Context of the Proliferation Phenotype in Head and Neck Squamous Cell Carcinoma” (2006) Mol Cancer Res. Mar;4(3):177-85.
  • Sevilla, A., Santos, C.R., Vega, F.M. and Lazo, P.A. “Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK” (2004) J Biol Chem, 279, 27458-27465.
  • Sevilla, A., Santos, C.R., Barcia, R., Vega, F.M. and Lazo, P.A. “c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)” (2004) Oncogene, 23, 8950-8958.
  • Santos, C.R., Vega, F.M., Blanco, S., Barcia, R. and Lazo, P.A. ”The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism” (2004) Virology, 328, 254-265.
  • Vega, F.M., Sevilla, A. and Lazo, P.A. “p53 Stabilization and accumulation induced by human vaccinia-related kinase 1” (2004) Mol Cell Biol, 24, 10366-10380.
  • Vega, F.M., Gonzalo, P., Gaspar, M.L. and Lazo, P.A. “Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development” (2003) FEBS Lett, 544, 176-180.
  • Barcia, R., Lopez-Borges, S., Vega, F.M. and Lazo, P.A. “Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1” (2002) Arch Biochem Biophys, 399, 1-5.
  • Martin, M.E., Hidalgo, J., Vega, F.M. and Velasco, A. “Trimeric G proteins modulate the dynamic interaction of PKAII with the Golgi complex” (1999) J Cell Sci, 112 (Pt 22), 3869-3878.
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