Dr Duran-Ruiz and colleagues have now published a new work evaluating the initial response of early Endothelial Progenitor Cells (EPC) from healthy individuals to factors released by arteries with atherosclerotic plaques. We have described the mobilization of these cells when in contact with the secretome from patient plaques, and analyze by proteomic methods the changes in protein expression on EPC cells. This work establishes a new ex-vivo model for the study of vascular cells in atherosclerosis and present a list of candidate proteins responsible for EPCs initial mobilization after atherosclerotic lesions.
Vega, F.M., Gautier, V., Fernandez-Ponce, C.M., Maarten, A.F., Tellez, J.T., Hernandez-Campos, J.A., Millan, J., Pardal, R., Garcia-Cózar, F.J., Aguado, E., Heck, A.J.R. and Duran-Ruiz, M.C. “The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo” (2017) J Mol Cell Cardiology. Feb18. [Epub ahead of print]