RhoB  activity mediates tumour recognition by T Cells

A recent paper describes a new function for RhoB in inside-out signalling leading to T cell activation by tumour cells. RhoB activation and re-localization induces a redistribution of the protein BTN3A1 associated to cytoskeletal changes. This step is necessary for its extracellular exposition in tumour cells and activation of a specific human T cell population (Vγ9Vδ2) with anti-tumour activity.  This new discovery places the already busy RhoB small GTPase in the field of cancer immunology.

Sebestyen, Z. et al. RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor. Cell Rep. 2016 May 31;15(9):1973-85. doi: 10.1016/j.celrep.2016.04.081.



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